I have been using TuneUp Utilities since 2007 version, and can say that each version has visible improvement compare with previous version.
Version 2010 is Windows 7 compatible, which is 1 of the reason I like it because I hardly use 2009 on my Windows 7. This version also introduce turbo mode that disable some unnecessary function to increase FPS of game. Its new live optimization increase system respond rate by increase or decrease priority of program depends on their power consumption.
To download go here:
Note that update the version may cause key to be blacklisted and unable to use anymore.